Review: Somatostatin analogues reduce blood products used in acute bleeding esophageal varices but do not reduce mortality.

نویسنده

  • Jacob Korula
چکیده

D a t a s o u r c e s Published and unpublished studies were identified by searching MEDLINE and the Cochrane Controlled Trials Register (last searched August 2001) with combinations and various forms of the terms somatostatin, octreotide, variceal, varices, bleed, hemorrhage, esophag, hematemesis, and melena; reviewing abstracts of conference proceedings and bibliographies of relevant studies; and contacting authors.

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منابع مشابه

Review: somatostatin and its analogues do not reduce mortality in acute bleeding esophageal varices.

M e t h o d s Data sources: MEDLINE (1966 to February 2004), the Cochrane Library, abstracts from conference proceedings, reference lists of trials, and contact with authors. Study selection and assessment: Randomized controlled trials (RCTs) in any language that compared somatostatin or its analogues with placebo or no treatment in patients with suspected or recently bleeding esophageal varice...

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Somatostatin analogues for acute bleeding oesophageal varices.

BACKGROUND Somatostatin and its derivatives are often used for emergency treatment of bleeding oesophageal varices in patients with cirrhosis of the liver. OBJECTIVES To study whether somatostatin or analogues improve survival or reduce the need for blood transfusions in patients with bleeding oesophageal varices. SEARCH STRATEGY MEDLINE and The Cochrane Library were searched; last search i...

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Sclerosing Therapy of Esophageal Varices

  SUMMARY Bleeding of esophageal varices have a high mortality rate, and medical management is usualy unsuccessful. Surgical methods such as vascular ligation or shunting are expensive. High risk procedures with high mortality. Endoscopic sclerotherapy was applied in 104 patients with acute bleeding of esophageal varices during a period of 5 years in a prospettive and retrospective study. Th...

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Can somatostatin control acute bleeding from oesophageal varices in Schistosoma mansoni patients?[ISRCTN63456799]

BACKGROUND Management of patients with bleeding oesophageal varices comprises of mainly diagnostic endoscopy, sclerotherapy and band ligation. One of the major problems to do any of the above is the active bleeding which makes any intervention difficult. The neuropeptide hormone somatostatin administered exogenously has caused a reduction in portal hypertension and variceal bleeding in patients...

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A meta-analysis of somatostatin versus vasopressin in the management of acute esophageal variceal hemorrhage.

BACKGROUND & AIMS Although sclerotherapy is the current standard therapy for bleeding esophageal varices, the best method for initial control is unclear. The aim of this meta-analysis was to compare the efficacy and toxicity of somatostatin and vasopressin in short-term treatment of hemorrhage from esophageal varices. METHODS Using MEDLINE, all randomized trials comparing somatostatin with va...

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عنوان ژورنال:
  • ACP journal club

دوره 137 3  شماره 

صفحات  -

تاریخ انتشار 2002